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Related Experiment Video

Updated: Jun 11, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Multiple-depth en face optical coherence tomography using active recirculation loops.

Liviu Neagu¹, Adrian Bradu, Lisha Ma

¹Applied Optics Group, School of Physical Sciences, University of Kent, CT2 7NH Canterbury, UK.

|July 3, 2010

Summary

This summary is machine-generated.

A new low-coherence interferometer enables deep imaging by compensating for optical losses. This allows for simultaneous, multi-depth en face optical coherence tomography imaging in biological samples.

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Area of Science:

Biomedical Optics
Optical Engineering
Microscopy

Background:

Optical coherence tomography (OCT) is a powerful imaging technique.
Achieving deep tissue imaging with OCT remains challenging due to signal attenuation.

Purpose of the Study:

To develop a novel low-coherence interferometer for enhanced imaging depth.
To demonstrate simultaneous multi-depth en face OCT imaging.

Main Methods:

Utilized a low-coherence interferometer with adjustable optical path length rings in each arm.
Compensated for ring-induced losses using semiconductor optical amplifiers.
Achieved interference after 18 traversals of the rings.

Main Results:

Successfully obtained interference of low-coherence light after multiple ring traversals.
Demonstrated simultaneous en face optical coherence tomography imaging.
Achieved imaging at five distinct depths within a Drosophila melanogaster (fruit fly) sample.

Conclusions:

The novel interferometer configuration effectively overcomes signal loss for deeper OCT penetration.
This technique enables multi-depth en face imaging, advancing biological sample analysis.