Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Microscopy Techniques

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An ultrasensitive energy-transfer based photoelectrochemical protein biosensor.

Chemical communications (Cambridge, England)·2016

Same author

Reproducibility and validity of an FFQ developed for adults in Nanjing, China.

The British journal of nutrition·2016

Same author

[Chemical Constituents from Leaves of Hibiscus syriacus and Their α-Glucosidase Inhibitory Activities].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2016

Same author

Quantifying Different Tactile Sensations Evoked by Cutaneous Electrical Stimulation Using Electroencephalography Features.

International journal of neural systems·2016

Same author

A Highly Sensitive Immunosorbent Assay Based on Biotinylated Graphene Oxide and the Quartz Crystal Microbalance.

ACS applied materials & interfaces·2016

Same author

Identification of Thyroid Hormones and Functional Characterization of Thyroid Hormone Receptor in the Pacific Oyster Crassostrea gigas Provide Insight into Evolution of the Thyroid Hormone System.

PloS one·2015

Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026

Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026

Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026

Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026

Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026

Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Microfiber-probe-based ultrasmall interferometric sensor.

Jun-long Kou¹, Jing Feng, Qian-jin Wang

¹College of Engineering and Applied Sciences and National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China.

|July 3, 2010

Summary

This summary is machine-generated.

We developed a compact microfiber interferometer for precise liquid refractive index measurement. This ultrasmall probe sensor offers high sensitivity and stability for detecting tiny biological samples.

More Related Videos

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection

Published on: June 13, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection

Published on: June 13, 2023

Area of Science:

Optical sensing
Nanofabrication
Biomedical instrumentation

Background:

Accurate liquid refractive index measurement is crucial for various scientific and industrial applications.
Existing fiber optic sensors can be bulky and expensive, limiting their use in microscale detection.

Purpose of the Study:

To develop an ultrasmall, highly sensitive microfiber-probe-based reflective interferometer for liquid refractive index measurement.
To demonstrate the sensor's potential for detecting sub-wavelength entities.

Main Methods:

Fabrication of a 3.5 micrometer micronotch cavity using focused ion beam micromachining.
Utilizing a microfiber-probe-based reflective interferometer design.
Characterization of the sensor's performance in liquid environments.

Main Results:

Achieved a high sensitivity of 110 nm/RIU (refractive index unit) in liquid.
Obtained an extinction ratio exceeding 20 dB.
Theoretical analysis revealed the device operates as a hybrid Fabry-Perot and modal interferometer.

Conclusions:

The developed microfiber probe sensor is compact, stable, and cost-effective compared to traditional fiber interferometers.
It shows significant potential for in-situ detection within sub-wavelength bubbles, droplets, or biocells.