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Updated: Jun 11, 2026

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Synthesis of alpha-arylated allylsilanes through palladium-catalyzed gamma-selective allyl-aryl coupling
Dong Li1, Tatsunori Tanaka, Hirohisa Ohmiya
1Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Abstract:
A palladium-catalyzed gamma-selective allyl-aryl coupling between gamma-silylated allylic esters and arylboronic acids produced alpha-arylated allylsilanes with E-alkene geometry. The reaction tolerated various functional groups in both the arylboronic acids and the allylic esters and afforded functionalized allylsilanes. The reaction of optically active allylic esters took place with excellent alpha-to-gamma chirality transfer with syn stereochemistry to give chiral allylsilanes.
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