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Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
Nanoceria as Antioxidant: Synthesis and Biomedical Applications.
A S Karakoti1, N A Monteiro-Riviere, R Aggarwal
1A.S. Karakoti is with the Surface Engineering and Nanotechnology Facility, Advanced Materials Processing and Analysis Center, Department of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, Florida. N.A. Monteiro-Riviere is with the Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, and the Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina. R. Aggarwal and R.J. Narayan are with the Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University. J.P. Davis is with the USDA ARS Market Quality and Handling Research Unit, Department of food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina. W.T. Self is with the Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida. J. McGinnis is with the Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma. S. Seal is with the Surface Engineering and Nanotechnology Facility, Advanced Materials Processing and Analysis Center, Department of Mechanical Materials and Aerospace Engineering, University of Central Florida; and also with the Nanoscience and Technology Center, University of Central Florida. Dr. Narayan can be reached at
Cerium oxide nanoparticles (nanoceria) show promise for treating disorders linked to reactive oxygen intermediates (ROI). Their radical-scavenging and self-regenerating properties make them suitable for biomedical applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Nanomaterials are increasingly studied for therapeutic uses.
- Cerium oxide (ceria) possesses unique redox properties beneficial for medical applications.
- Reactive oxygen intermediates (ROI) are implicated in various medical disorders.
Purpose of the Study:
- To explore the therapeutic potential of cerium oxide nanoparticles (nanoceria).
- To investigate the radical-scavenging and regenerative capabilities of nanoceria.
- To assess the biocompatibility and cell viability of nanoceria for biomedical applications.
Main Methods:
- Review of studies on nanomaterial therapeutic applications.
- Analysis of cerium oxide's redox properties and radical-scavenging mechanisms.
- Evaluation of nanoceria synthesis in biocompatible media and cell viability assays.
Main Results:
- Nanoceria effectively scavenge free radicals, mitigating ROI-related damage.
- Nanoceria exhibit autocatalytic self-regeneration, enhancing their stability and efficacy.
- Synthesis in biocompatible media and demonstrated cell viability support potential biomedical use.
Conclusions:
- Nanoceria are a promising therapeutic agent for ROI-mediated diseases.
- The unique properties of nanoceria, including regeneration, are advantageous for medical treatments.
- Further research into nanoceria's biocompatibility and efficacy is warranted for clinical translation.
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