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Flow Cytometry01:23

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Analytical parameters for amplitude-modulated multiplexed flow analysis.

Yohei Kurokawa1, Masaki Takeuchi, Hideji Tanaka

  • 1Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|July 16, 2010
PubMed
Summary
This summary is machine-generated.

This study enhances amplitude-modulated multiplexed flow analysis for faster sample throughput. The optimized system accurately determines chloride ions in water samples using fast Fourier transform (FFT) signal deconvolution.

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Area of Science:

  • Analytical Chemistry
  • Flow Analysis

Background:

  • Amplitude-modulated multiplexed flow analysis is a novel technique for high-throughput analysis.
  • Optimization is needed to improve its performance and applicability.

Purpose of the Study:

  • To investigate and optimize analytical conditions for amplitude-modulated multiplexed flow analysis.
  • To enhance sample throughput rate and evaluate the system's performance for analyte determination.

Main Methods:

  • Independent variation of sample flow rates using sinusoidal voltage signals.
  • Signal deconvolution using fast Fourier transform (FFT) for separating multiplexed information.
  • Optimization of modulation period and system configuration using Malachite Green (MG).

Main Results:

  • Optimized conditions achieved a modulation period as low as 5 s.
  • High linearity (r(2) = 0.999) and a low limit of detection (1.3 µmol dm⁻³) for MG.
  • Accurate determination of chloride ions in real water samples with satisfactory recoveries (~100%).

Conclusions:

  • The developed amplitude-modulated multiplexed flow analysis system offers high sample throughput.
  • FFT-based deconvolution enables accurate real-time analysis of multiple analytes.
  • The system is effective for determining chloride ions in environmental water samples.