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Updated: Jun 10, 2026
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
The chromosomal translocation (11;14) (p13; q11) in acute B-Cell lymphocytic leukemia
Kourong Miao1, Jianyong Li, Hairong Qiu
1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, China.
Background:
Cytogenetic abnormalities are the most important independent prognostic factors of acute leukemia and imply the potential molecular mechanism of the disease. Translocation (11;14)(p13;q11) has been predominantly found in T-cell acute lymphocytic leukemia (ALL) but is rare in B-cell ALL.
Case Report:
We present the case of a 30-year-old male patient, who presented with symptomatic anemia, thrombocytopenia and leukocytosis. Bone marrow aspirate smear showed hypercellularity with 90.4% of blast cells, which were negative for peroxidase reaction and partially positive for periodic acid-Schiff reaction. Immunophenotyping analysis was positive for CD34, HLA-DR, CD13, CD33, CD19, CD22, cCD79c, and negative for CD2, CD3, CD7, CD8, CD10, CD20, cCD3. Conventional cytogenetic study by R-banding showed complex chromosome aberrations involving t(11;14)(p13;q11) with the following karyotype: 46,XY,t (11;14)(p13;q11)[2]/46,idem,add2(q?)[2]/46,XY,add16(p?) [3]/46,XY[13]. Fluorescence in situ hybridization analysis indicated the translocation of chromosomes 11 and 14, and was negative for BCR/ABL fusion. The patient went into complete remission after the first induction chemotherapy (ALL-IC-BFM 2002 regimen), but he relapsed and died after 4 months.
Conclusions:
Translocation (11;14) (p13;q11) in B-cell ALL is rare, but it is worth exploring the molecular mechanisms and discovering the prognostic value in more B-cell ALL patients.
