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Updated: Jun 10, 2026

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery
Published on: August 9, 2024
Brainstem infarct presenting as torsades de pointes.
Sivakumar Ardhanari1, Balashankar Gomathi S, L Anita
1Institute of Cardiovascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu.
Severe alkalosis can cause hypokalemia, leading to dangerous heart rhythms like torsades de pointes. This case highlights central neurogenic hyperventilation from a brainstem infarct causing refractory ventricular tachyarrhythmia due to secondary hypokalemia.
Area of Science:
- Neurology
- Cardiology
- Critical Care Medicine
Background:
- Severe alkalosis is known to cause hypokalemia, a condition that can lead to cardiac arrhythmias.
- Hypokalemia can prolong the QT interval, increasing the risk of potentially fatal ventricular tachyarrhythmias such as torsades de pointes.
Observation:
- This report details a rare case of central neurogenic hyperventilation.
- The hyperventilation stemmed from a brainstem infarct.
- The patient presented with refractory ventricular tachyarrhythmia secondary to hypokalemia.
Findings:
- Central neurogenic hyperventilation can precipitate severe alkalosis.
- This alkalosis, in turn, can lead to profound hypokalemia.
- The resulting hypokalemia was the primary driver of the refractory ventricular tachyarrhythmia.
Implications:
- This case underscores the critical link between respiratory and metabolic disturbances in neurological injury.
- Recognizing central neurogenic hyperventilation is crucial for managing electrolyte imbalances and cardiac complications.
- Early diagnosis and management of hypokalemia are vital in patients with brainstem infarcts to prevent life-threatening arrhythmias.
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