Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive value of gB2 antibodies for maternal-fetal transmission after primary cytomegalovirus infection treated with valacyclovir.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Surgical interventions for fetal hydrocephalus: systematic review.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Aspirin delays the metabolic clock of gestation in women at risk of preeclampsia: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Complication rate after termination of pregnancy for fetal defects.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Re-evaluating diagnostic thresholds for intrahepatic cholestasis of pregnancy: case-control and cohort study.

BJOG : an international journal of obstetrics and gynaecology·2021
Same author

Detection of 69,XXX karyotype in circulating trophoblasts using fluorescence in-situ hybridization after enrichment using novel high-throughput microfluidic platform.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021

Related Experiment Video

Updated: Jun 10, 2026

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
07:04

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

Additional first-trimester ultrasound markers.

J Sonek1, K Nicolaides

  • 1Wright State University, Dayton, OH, USA. jdsonek@mvh.org

Clinics in Laboratory Medicine
|July 20, 2010
PubMed
Summary
This summary is machine-generated.

First-trimester ultrasound screening for fetal defects is enhanced by novel markers. These include nasal bone evaluation, fronto-maxillary angle, and Doppler flow across the tricuspid valve and ductus venosus, improving chromosomal defect detection.

More Related Videos

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
06:43

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Is My Mouse Pregnant? High-Frequency Ultrasound Assessment
02:39

Is My Mouse Pregnant? High-Frequency Ultrasound Assessment

Published on: March 18, 2021

Related Experiment Videos

Last Updated: Jun 10, 2026

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
07:04

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
06:43

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Is My Mouse Pregnant? High-Frequency Ultrasound Assessment
02:39

Is My Mouse Pregnant? High-Frequency Ultrasound Assessment

Published on: March 18, 2021

Area of Science:

  • Maternal-fetal medicine
  • Prenatal diagnostics
  • Medical imaging

Background:

  • First-trimester ultrasound (11-13+6 weeks) is crucial for dating pregnancies and screening for fetal abnormalities.
  • Current screening for chromosomal defects relies on nuchal translucency and maternal serum markers (free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A).
  • Advances in ultrasound technology have introduced new markers to enhance screening accuracy.

Purpose of the Study:

  • To review the utility of first-trimester ultrasound in pregnancy management.
  • To highlight the role of nuchal translucency and serum markers in chromosomal defect screening.
  • To introduce and discuss novel ultrasound markers that improve first-trimester screening performance.

Main Methods:

  • Review of established and emerging ultrasound techniques for first-trimester fetal assessment.
  • Integration of nuchal translucency measurement with maternal serum markers.
  • Inclusion of novel markers: nasal bone evaluation, fronto-maxillary angle, and Doppler assessments (tricuspid valve, ductus venosus).

Main Results:

  • Nuchal translucency and serum markers form the basis of first-trimester screening for chromosomal abnormalities.
  • Novel ultrasound markers significantly enhance the performance of first-trimester screening.
  • These additional markers provide more comprehensive data for risk assessment of fetal defects.

Conclusions:

  • First-trimester ultrasound is a vital tool for accurate dating and fetal defect screening.
  • The combination of traditional and novel ultrasound markers improves the detection rates of chromosomal abnormalities.
  • Enhanced ultrasound protocols offer improved prenatal diagnostic capabilities.