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Related Concept Videos

Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Related Experiment Video

Updated: Jun 10, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Recurrent bullous scabies.

David Serra1, José Pedro Reis, Angelina Mariano

  • 1Dermatology Department, University Hospital of Coimbra, Portugal. david.serra.fernandes@gmail.com

Journal of Cutaneous Medicine and Surgery
|July 21, 2010
PubMed
Summary
This summary is machine-generated.

Bullous scabies, a rare presentation of this mite infestation, can mimic other blistering conditions. This case highlights diagnostic challenges and the need for effective institutional control to prevent recurrence.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Published on: December 18, 2012

Area of Science:

  • Dermatology
  • Parasitology

Background:

  • Scabies is a common pruritic skin infestation.
  • Diagnosis typically relies on clinical signs like burrows.
  • Atypical presentations, such as bullous lesions, are rare.

Observation:

  • An elderly woman presented with a blistering eruption resembling bullous pemphigoid.
  • Histopathology showed subepidermal blistering with eosinophils.
  • Dermoscopy and skin scrapings confirmed scabies mites.

Findings:

  • The patient was diagnosed with bullous scabies.
  • Treatment with topical lindane was initially effective.
  • Recurrences occurred due to ongoing scabies transmission in her institution.

Implications:

  • This case emphasizes the mite's role in blister formation.
  • It highlights difficulties in diagnosing and managing scabies, especially in institutional settings.
  • Effective scabies control measures are crucial to prevent recurrent, atypical infestations.