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Allergic Reactions

Allergic Reactions

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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

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Octocrylene, an emerging photoallergen.

Martine Avenel-Audran¹, Hervé Dutartre, An Goossens

¹Service de Dermatologie, Centre Hospitalier Universitaire, Angers CEDEX 9, France. MaAvenel-Audran@chu-angers.fr

Archives of Dermatology

|July 21, 2010

Summary

This summary is machine-generated.

Octocrylene is a significant allergen causing contact dermatitis in children and photoallergic reactions in adults, often linked to ketoprofen photoallergy. Patients with ketoprofen photoallergy frequently react to octocrylene, requiring avoidance of certain sunscreens.

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Published on: July 22, 2021

Area of Science:

Dermatology
Allergology
Photodermatology

Background:

Octocrylene is an emerging photoallergen.
This study investigates 50 cases of photoallergic contact dermatitis linked to octocrylene.
An unexpected association between octocrylene photoallergy and prior ketoprofen photoallergy in adults is highlighted.

Purpose of the Study:

To report and discuss cases of photoallergic contact dermatitis caused by octocrylene.
To identify the prevalence of octocrylene allergy in different patient groups.
To explore the link between ketoprofen photoallergy and octocrylene sensitization.

Main Methods:

Patients were categorized into three groups: children (group A), adults with sunscreen photoallergy (group B), and adults with ketoprofen photoallergy tested for octocrylene (group C).
Patch testing and photopatch testing were conducted to assess reactions to octocrylene and other allergens.
Clinical histories of photoallergy and reactions to specific allergens were analyzed.

Main Results:

A high percentage of patients across all groups showed positive reactions to octocrylene.
Photopatch test reactions to octocrylene were common, particularly in adults with a history of ketoprofen photoallergy.
Many patients with ketoprofen photoallergy also reacted to other common allergens like fragrance components.

Conclusions:

Octocrylene is a potent allergen causing contact dermatitis in children and photoallergic contact dermatitis in adults.
A significant association exists between ketoprofen photoallergy and positive photopatch test reactions to octocrylene.
Patients with ketoprofen photoallergy should be informed about sunscreens containing octocrylene, benzophenone-3, or fragrances.