Related Experiment Video
Updated: Jun 10, 2026
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
[Effect of hBMP-7 gene modified bone marrow stromal cells on periodontal tissue regeneration]
Yan-Fen Li1, Fu-Hua Yan, Quan Zhong
1Department of Periodontology, Affiliate Stomatological Hospital, Fujian Medical University, Fuzhou 350002, China.
Objective:
To estimate the potential effects of hBMP-7 gene transfected bone marrow stromal cells (BMSC) and to provide a new way for repairing the periodontal defects.
Methods:
A total of 30 experimental class II furcation defects in five Beagle dogs were created surgically. The transfected and non-transfected BMSC were seeded in collagen membrane at an initial concentration of 1 x 10(7)/ml and transplanted into experimental class II furcation defects. The animals were sacrificed at 12 weeks post-operation and periodontal regeneration was evaluated by the histological and morphometric analysis.
Results:
In both experimental and control groups, there were different extents of regeneration. The percentage of new alveolar area in transfected and non-transfected BMSC were significantly higher than the control (P < 0.05). And there was also significant difference between two experimental groups (P < 0.05). The percentage of new cementum length in two experimental groups were significantly higher than the control (P < 0.05). But there was no significant difference between two BMSCs groups (P > 0.05).
Conclusion:
hBMP-7 gene enhanced tissue engineering could be a better way to repair the periodontal defects.
