[Urinary de-diversion after diversion with chronic bladder contamination. An experimental study in male rats]

We have carried out an experimental model of urinary diversion and dis-diversion on male Wistar rats in order to study the complications that are produced after diversion, as well as to see whether the alterations continue unchanged, or increase, or diminish after dis-diversion. The following experimental design was used: a control group made up of 48 animals an a problem group of 200 animals all submitted to vesicosigmoidostomy of which 100 were designed to be subsequently dis-diverted. The sacrificed animals (n = 112) were studied for somatic, biochemical and histological parameters. Statistical comparison of the problem group with the controls showed significant differences for the somatic and biochemical parameters, especially in the form of weight-size retardation, increase of urea, creatinine, calcium, phosphorus, uric acid, cholesterol, transaminase, alkaline phosphatase, sodium and chlorine and decrease in albumin and total proteins. After dis-diversion there is an improvement of some of these parameters without reaching total normalization. This leads us to think that either the lesions are irreversible, or more time after dis-diversion is needed for there to be reversibility. We also describe the histological lesions found at the level of the vesicointestinal anastomosis, and the mortality of our series which is higher than that presented by females, a fact inducing us to think that factors exist in the male which increase the mortality.