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Related Experiment Video

Updated: Jun 10, 2026

Transvaginal Mesh Insertion in the Ovine Model
10:32

Transvaginal Mesh Insertion in the Ovine Model

Published on: July 27, 2017

Vaginal mesh for prolapse: a randomized controlled trial.

Cheryl B Iglesia1, Andrew I Sokol, Eric R Sokol

  • 1From Washington Hospital Center, Washington, DC; Stanford University, Stanford, California; MedStar Research Institute, Washington, DC; and Rush Medical College, Chicago, Illinois.

Obstetrics and Gynecology
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

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This study found that vaginal prolapse surgery with mesh had a high erosion rate and no improved cure rates compared to traditional surgery without mesh. The findings question the benefit of using synthetic polypropylene mesh in these repairs.

Area of Science:

  • Urogynecology and Pelvic Reconstructive Surgery
  • Biomaterials in Medical Devices
  • Randomized Controlled Trials in Surgical Outcomes

Background:

  • Pelvic organ prolapse (POP) affects many women, with surgical repair being a common treatment.
  • Vaginal surgery with synthetic mesh has been used to augment traditional prolapse repairs.
  • Concerns exist regarding mesh-related complications and overall efficacy.

Purpose of the Study:

  • To compare the 3-month outcomes of vaginal prolapse repair with and without synthetic mesh.
  • To evaluate objective and subjective cure rates, as well as complication rates, between the two surgical approaches.

Main Methods:

  • A double-blind, multicenter randomized controlled trial (RCT) involving women with POP quantification stages 2-4.
  • Participants were randomized to either vaginal colpopexy with mesh or traditional vaginal colpopexy without mesh.

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Last Updated: Jun 10, 2026

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  • Primary outcome was objective treatment success (POP-Q stage ≤1) at 3 months; secondary outcomes included quality of life and complications.

    • Main Results:

    • The study was halted early due to mesh erosion concerns.
    • No statistically significant difference in overall objective or subjective cure rates between mesh and no-mesh groups (59.4% vs. 70.4% recurrence).
    • A high rate of vaginal mesh erosion (15.6%) was observed, with other complications occurring only in the mesh group.

    Conclusions:

    • Vaginal prolapse repair with synthetic mesh demonstrated a high mesh erosion rate at 3 months.
    • There was no significant difference in objective or subjective cure rates compared to traditional repair without mesh.
    • The study suggests that the value of additive synthetic polypropylene mesh for vaginal prolapse repair is questionable.