Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Bulimia Nervosa

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...

Binge Eating Disorders

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Maturity Onset Diabetes of the Young (MODY): French National Diagnosis and Care Protocol (PNDS, Protocole National de Diagnostic et de Soins).

Orphanet journal of rare diseases·2026

Same author

[Trace elements and vitamins status during pregnancy].

Annales de biologie clinique·2026

Same author

Impact of high intensity physical activity compared to routine counseling on renal function decline in patients with type 2 diabetes at high risk for kidney disease - the ACTIDIANE randomized controlled trial.

Diabetes & metabolism·2026

Same author

[Main physiological and biological changes in pregnant women].

Annales de biologie clinique·2026

Same author

Co-occurrence of Loss-of-Function GCK and ABCC8 Variants in a Pedigree With a Spectrum of Dysglycemia.

Diabetes·2026

Same author

[Does bariatric surgery still have a place in the treatment of type 2 diabetes?]

La Revue du praticien·2025

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

[Obesity, a disease].

Arnaud Basdevant¹, Cécile Ciangura

¹Pôle endocrinologie, diabètologie, nutrition, Hôpital de la Pitié-Salpêtrère, 47 bid de l'Hôpital, 75651 Paris cedex 13. arnaud.basdevant@psl.aphp.fr

Bulletin De L'Academie Nationale De Medecine

|July 31, 2010

Summary

Obesity is recognized as a chronic disease by the World Health Organization, driven by global spread and rising healthcare costs. Management requires individualized approaches, from prevention to surgical interventions.

Area of Science:

Public Health
Endocrinology
Epidemiology

Background:

Obesity's classification evolved from a risk factor to a disease by the World Health Organization in 1997.
Epidemiological data reveals the global prevalence of obesity.
Increasing healthcare expenditures are linked to obesity-related conditions like type 2 diabetes.

Purpose of the Study:

To highlight the disease status of obesity.
To discuss the factors contributing to its recognition as a disease.
To outline the spectrum of management strategies for obesity.

Main Methods:

Review of epidemiological data on obesity prevalence.
Analysis of pathophysiological concepts related to obesity.
Examination of healthcare expenditure trends associated with obesity.

More Related Videos

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Related Experiment Videos

Last Updated: Jun 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Main Results:

Global obesity rates have significantly increased.
Obesity is associated with a rise in type 2 diabetes and associated healthcare costs.
Advancements in understanding obesity's pathophysiology support its disease classification.

Conclusions:

Obesity is a chronic, progressive disease requiring comprehensive management.
Management strategies must be tailored to individual patient needs.
A multi-faceted approach encompassing prevention, lifestyle changes, and medical or surgical interventions is necessary.