Improvement of Functional Magnetic Resonance Imaging by a Novel Fibre-optic Device and 3D Software

This report describes three years of clinical experience with a new set of devices aimed at improving functional MRI of speech areas. They provide a valuable tool for pre-operative definition of hemispheric localization and spatial extension of these areas, especially in left-handed persons. The fibre-optic device described here transmits stimuli for cognitive tasks to patients undergoing MR investigations. Cognitive tasks elicit a defined brain activity lasting for several minutes. The resultant metabolic changes are detectable by functional MRI. The software (FIT ware) applied to process raw data allows semi-automated segmentation of the brain so as to obtain 3D images. Furthermore it allows the superposition of functional data. The effectiveness of the equipment was assessed on the basis of data from 140 fMRI studies. Intra-operative verification in eight patients with tumours located in the speech areas showed that the new set-up identified the speech-dominant side in each case and located speech areas in accordance with electrophysiological procedures.