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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Stenting treatment for intra- and extra-cranial atherosclerotic diseases
1Department of Neurosurgery, Kochi Medical School, Okoh-cho, Nankoku City, Kochi, Japan.
Insights
Stenting offers a safe and effective treatment for atherosclerotic diseases in extra- and intra-cranial arteries, particularly for stenoses not treatable with balloon angioplasty. The procedure demonstrated a high success rate with low morbidity.
Area of Science:
- Neurology
- Vascular Surgery
- Interventional Cardiology
Background:
- Atherosclerotic diseases affecting extra- and intra-cranial arteries pose significant risks.
- Standard balloon angioplasty is not always suitable for high-grade stenoses.
Purpose of the Study:
- To evaluate the efficacy, safety, and short-term outcomes of stenting for extra- and intra-cranial atherosclerotic diseases.
- To assess stenting as a treatment modality for complex arterial stenoses.
Main Methods:
- Forty-one patients with atherosclerotic diseases underwent stenting using coronary and biliary stents.
- Procedures included stenting for both intra-cranial (11 patients) and extra-cranial (30 patients) arterial stenoses.
- Follow-up included arteriography at six months for restenosis assessment.
Main Results:
- Successful stent implantation was achieved in 88% of lesions (36/41) with an overall procedural morbidity rate of 2%.
- Intra-cranial stenting showed a 64% procedural and clinical success rate with 0% morbidity.
- Overall clinical success was 80% (33/41), with 12% restenosis at six months and no stent-related ischemic events or deformation.
Conclusions:
- Endovascular stent placement is a safe and effective treatment for extra- and intra-cranial atherosclerotic lesions not amenable to balloon angioplasty.
- Stenting provides a viable therapeutic option for complex atherosclerotic arterial disease.
- The study highlights the potential of stenting in improving outcomes for challenging vascular cases.
Abstract:
The purpose of this study was to investigate the effect, safety and short-term outcome of stenting treatment for extra- and intra-cranial atherosclerotic diseases. Forty-one patients underwent stenting treatment using coronary and biliary stents. Eleven patients had tubular or diffuse high-grade stenoses not amenable to standard balloon angioplasty involving intra-cranial arteries, while in thirty, extra-cranial arteries were involved. Stents were successfully implanted in 36 out of 41 lesions (88%) with 2% (1/41) of overall procedural morbidity rate. Procedural and clinical success rate of intra-cranial stent placement was 64% (7/11) and no complications occurred during or after intra-cranial stent placement: the morbidity rate was 0%. Hyperperfusion injury occurred in two patients after successful implantation of stents in subtotal occlusion of the internal carotid artery, and consequently the overall clinical success rate was 80% (33/41). Restenosis occurred in four (12%) out of 33 patients who underwent six month follow-up arteriography. No ischemic attacks or stent-deformation occurred during follow-up after stenting treatment. For lesions not amenable to standard balloon angioplasty, endovascular stent placement seems to be a safe and effective treatment of modality.
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