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Updated: Jun 10, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
[Catecholaminergic polymorphic ventricular tachycardia is a rare inherited heart disease]
Anders Gaarsdal Holst1, Jacob Tfelt-Hansen, Morten S Olesen
1Københavns Universitet, Danmarks Nationale Grundforskningsfonds Center for Hjertearytmi, Rigshospitalet, Hjertecentret, Hjertemedicinsk Klinik B, Laboratorium for Molekylaer Kardiologi. anders@kanten.dk
Abstract:
Catecholaminergic polymorphic ventricular tachycardia is a rare inherited heart disease, which can lead to life-threatening ventricular arrhythmias in patients with a structurally normal heart. The age of onset is usually between two and 12 years and the initial symptom is frequently syncope or cardiac arrest. The arrhythmias are usually triggered by exercise or emotional affection. The diagnosis is often made using exercise electrocardiogram, which typically triggers arrhythmias. The treatment consists of beta blockers, frequently in combination with implantation of a cardioverter-defibrillator.
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