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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

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Related Experiment Video

Updated: Jun 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Marginal zone B-cell lymphomas.

Xavier Sagaert1, Thomas Tousseyn

  • 1Department of Pathology, University Hospitals of K.U.Leuven, Leuven, Belgium. xavier.sagaert@uzleuven.be

Discovery Medicine
|July 31, 2010
PubMed
Summary
This summary is machine-generated.

Marginal-zone lymphoma (MZL) includes three B-cell non-Hodgkin

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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Last Updated: Jun 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
08:31

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Marginal-zone lymphoma (MZL) is a group of indolent B-cell non-Hodgkin's lymphomas.
  • It comprises three distinct subtypes: extranodal MZL (MALT lymphoma), nodal MZL, and splenic MZL.
  • These subtypes originate from the marginal zone B-cell but exhibit unique clinical and biological features based on their site of origin.

Purpose of the Study:

  • To provide a concise overview of the three marginal-zone lymphoma subtypes.
  • To summarize recent advancements in understanding the genetic aberrations and pathogenic mechanisms of MZL.
  • To highlight the clinical and biological variations among MZL subtypes.

Main Methods:

  • Literature review of recent research on marginal-zone lymphoma.
  • Synthesis of data on genetic aberrations and pathogenic mechanisms.
  • Comparative analysis of clinical and biological characteristics of MZL subtypes.

Main Results:

  • Recent decades have yielded significant new data on the genetic landscape and pathogenesis of MZL.
  • Despite a common cell of origin, MZL subtypes display distinct variations.
  • Understanding these variations is crucial for diagnosis and treatment.

Conclusions:

  • Marginal-zone lymphoma is a heterogeneous group of B-cell lymphomas with distinct subtypes.
  • Ongoing research continues to elucidate the complex genetic and pathogenic mechanisms driving these diseases.
  • Further investigation into subtype-specific characteristics is essential for advancing patient care.