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Volume exclusion and soft interaction effects on protein stability under crowded conditions

Andrew C Miklos1, Conggang Li, Naima G Sharaf

  • 1Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Biochemistry
|August 3, 2010
PubMed
Summary

Macromolecular crowding significantly stabilizes proteins, with effects explained by particle exclusion, confinement, and weak binding. These soft interactions are crucial for understanding protein behavior in crowded biological environments.

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