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Published on: March 15, 2020
Influence of temperature on embolisation with cyanoacrylate
S Bracard1, J M Macho-Fernández, X Wang
1Department of Diagnostic and Interventional Neuroradiology, University Hospital; Nancy Cedex, France.
Summary
Warming histoacryl and lipiodol mixtures to 40°C significantly reduces viscosity, improving injection control and radiological visualization. Visualization is maintained even with 90% histoacryl, eliminating the need for additives.
Area of Science:
- Interventional Radiology
- Materials Science
Background:
- Histoacryl and Lipiodol are commonly used in embolization procedures.
- Optimizing the physical properties of these mixtures is crucial for effective delivery and visualization.
Purpose of the Study:
- To investigate the impact of temperature and concentration on the viscosity of Histoacryl-Lipiodol mixtures.
- To assess the radiological visualization of these mixtures under varying conditions.
Main Methods:
- Viscosity measurements of Histoacryl-Lipiodol mixtures at different temperatures and concentrations.
- Radiological evaluation using CT and DSA after injection into polyethylene tubes.
Main Results:
- Mixture viscosity is directly proportional to Lipiodol concentration and inversely proportional to temperature.
- Radiological visualization was maintained up to 90% Histoacryl concentration.
- Warming mixtures to approximately 40°C significantly decreased viscosity, enhancing injection manageability.
Conclusions:
- Temperature is a critical factor in controlling Histoacryl-Lipiodol mixture viscosity for embolization.
- Additives like tantalum or tungsten are unnecessary for visualization when Histoacryl concentration is below 90%.
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