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Related Concept Videos

Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Complexation Equilibria: Overview01:23

Complexation Equilibria: Overview

Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...
Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Noncovalent encapsulation stabilities in supramolecular nanoassemblies.

Siriporn Jiwpanich1, Ja-Hyoung Ryu, Sean Bickerton

  • 1Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Journal of the American Chemical Society
|August 5, 2010
PubMed
Summary

We developed a fluorescence method to measure how quickly guest molecules exchange in nanoassemblies. This helps assess the stability and potential leakage of drug delivery vehicles.

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Area of Science:

  • Supramolecular chemistry
  • Materials science
  • Biophysics

Background:

  • Exchange dynamics of guest molecules in nanoassemblies are crucial for drug delivery vehicle stability.
  • High exchange rates indicate a propensity for nanocarriers to be leaky, compromising drug delivery.
  • Understanding these dynamics is key to designing effective and stable nanocarriers.

Purpose of the Study:

  • To develop and present a novel method for evaluating guest exchange dynamics in aqueous solutions.
  • To quantify the stability of guest molecule encapsulation within various nanoassemblies.
  • To establish a reliable technique for assessing the integrity of drug delivery systems.

Main Methods:

  • Utilized Fluorescence Resonance Energy Transfer (FRET) as the core detection mechanism.
  • Employed FRET to monitor the exchange kinetics of lipophilic guest molecules.
  • Applied the method to analyze encapsulation stability in polymeric nanogels and amphiphilic nanoassemblies.

Main Results:

  • Successfully demonstrated a FRET-based approach to measure guest exchange dynamics.
  • Quantified the exchange rates, providing insights into the stability of encapsulation.
  • Validated the method's applicability across different types of nanoassemblies.

Conclusions:

  • The FRET-based method offers a robust tool for evaluating guest exchange dynamics in aqueous nanoassemblies.
  • This technique is valuable for assessing the stability and potential leakage of drug delivery vehicles.
  • The findings contribute to the development of more stable and efficient nanocarrier systems for drug delivery.