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Related Experiment Video

Updated: Jun 10, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Orbital lymphoma presenting with choroidal detachments.

Dena S Hammoudi1, Nancy A Tucker, Bernard Fernandes

  • 1Department of Ophthalmology and Vision Sciences, The University of Toronto, Toronto, Ontario, Canada. dhammoudi@hotmail.com

Ophthalmic Plastic and Reconstructive Surgery
|August 5, 2010
PubMed
Summary

This case report details a rare orbital B-cell lymphoma with unusual symptoms, including choroidal effusion and optic disk swelling. Diagnosis was confirmed via biopsy, highlighting a unique presentation of extranodal marginal zone B-cell lymphoma.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Orbital lymphomas are rare neoplasms, with extranodal marginal zone B-cell lymphoma (EMZL) being a subtype that can affect ocular tissues.
  • Primary orbital lymphomas typically present with proptosis, diplopia, or decreased vision, but atypical presentations can occur.

Observation:

  • A patient presented with unilateral choroidal effusion and optic disk swelling, unusual initial signs for orbital pathology.
  • Imaging revealed an intraconal orbital mass encasing the optic nerve and causing globe indentation, suggesting a space-occupying lesion.

Findings:

  • Histopathological and immunohistochemical analysis of the biopsied mass confirmed the diagnosis of extranodal marginal zone B-cell lymphoma.
  • This represents the first documented case of primary orbital lymphoma presenting with choroidal effusion.

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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Implications:

  • This case expands the spectrum of clinical presentations for orbital EMZL, emphasizing the need for thorough investigation of atypical symptoms.
  • Recognizing this rare presentation is crucial for timely diagnosis and appropriate management of orbital B-cell lymphoma, potentially improving patient outcomes.