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[Effect of endogenous H2S on platelet L-Arg transport]
Wen-zhuo Duan1, Yi-peng Wang, Hai-min Gong
1Weifang Medical College, Weifang 261042, China. dwenzhy@hotmail.com
Objective:
To observe the effect of novel air neuromodulator H2S on platelet function of L-Arg transport for discussing H2S of effect on platelet function.
Methods:
Saturate H2S solution as donate made rat rich platelet plasma and pre-incubation rat platelet with different density of H2S. To measure the velocity of L-Arg transport in platelet by radioactivity technique.
Results:
At different concentrations of H2S (6.25, 12.5, 25, 50, 100 micromol/L), the velocity of L-Arg transport was lower than that in control. H2S reduced rapidly the Vmax and velocity of L-Arg transport in platelet (P < 0.05) and this effect had no effect to Km.
Conclusion:
H2S can affect platelet function by changing rapidly platelet L-Arg transport system function.
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