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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Published on: November 5, 2019

Sickle cell disease in pregnancy.

Dennie T Rogers¹, Robert Molokie

¹Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, M/C 808, Chicago, IL 60612, USA. droger3@uic.edu

Obstetrics and Gynecology Clinics of North America

|August 6, 2010

Summary

Pregnancy with sickle cell disease (SSD) presents challenges, but outcomes have improved. Optimal management focuses on preventing complications and ensuring maternal and fetal health through a multidisciplinary approach.

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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Hematology
Obstetrics
Maternal-Fetal Medicine

Background:

Sickle cell disease (SSD) comprises various sickle hemoglobinopathies.
Predicting the clinical course of SSD during pregnancy is challenging.
Pregnancy in women with SSD is associated with increased morbidity and mortality risks.

Purpose of the Study:

To examine pregnancy-associated complications in sickle cell disease.
To review the management strategies for pregnant women with sickle cell disorders.
To highlight improvements in outcomes and persistent risks.

Main Methods:

Review of literature on pregnancy-associated complications in SSD.
Analysis of management approaches for sickle cell disorders in pregnant women.
Synthesis of current best practices for optimizing maternal and fetal health.

Main Results:

Outcomes for pregnant women with SSD have improved, with a majority achieving successful live births.
Despite improvements, pregnancy remains a high-risk period for SSD patients.
Key management goals include preventing pain crises and organ damage, optimizing fetal well-being, and minimizing maternal mortality.

Conclusions:

Successful live birth is now achievable for most pregnant women with SSD.
Pregnancy necessitates vigilant management to mitigate risks of morbidity and mortality.
A multidisciplinary team approach is crucial for effective management, focusing on pain crisis prevention and prompt pain relief.