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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

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Related Experiment Video

Updated: Jun 10, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Update on estrogens and the skeleton.

Sundeep Khosla1

  • 1Endocrine Research Unit, Guggenheim 7, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. khosla.sundeep@mayo.edu

The Journal of Clinical Endocrinology and Metabolism
|August 6, 2010
PubMed
Summary
This summary is machine-generated.

Despite past concerns, estrogen

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Published on: June 8, 2014

Area of Science:

  • Bone biology and endocrinology
  • Postmenopausal health
  • Osteoporosis research

Background:

  • The Women's Health Initiative trial raised safety concerns about estrogen therapy for bone loss prevention.
  • This led to a decline in estrogen use for postmenopausal women.
  • The relevance of estrogen's role in bone regulation is questioned.

Purpose of the Study:

  • To evaluate the continued relevance of estrogen in bone regulation.
  • To explore potential therapeutic targets for osteoporosis.
  • To assess estrogen's impact on bone in postmenopausal women.

Main Methods:

  • Literature review of PubMed.
  • Synthesis of the author's expertise in the field.

Main Results:

  • Estrogen's effects on bone remain crucial for osteoporosis research and drug development.
  • Low estrogen levels significantly impact bone turnover in postmenopausal women.
  • Estrogen therapy may offer skeletal benefits with minimal reproductive risks.

Conclusions:

  • Estrogen and bone research continues to provide vital insights.
  • Findings impact both basic science and clinical applications for aging populations.
  • Estrogen's role in bone health remains a significant area of study.