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Cucullamide, a new putrescine bisamide from Amoora cucullata
Mohamed Saleh Abdelfattah1, Kazufumi Toume, Firoj Ahmed
1Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Japan.
Chemical & Pharmaceutical Bulletin
|August 6, 2010
Summary
A new compound, cucullamide, was discovered in Amoora cucullata leaves. This research details its isolation and structural elucidation using advanced spectroscopic methods.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Amoora cucullata is a plant species known for its potential bioactive compounds.
- Phytochemical investigations aim to discover novel molecules from natural sources.
- Putrescine bisamide derivatives represent a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new natural products from the leaves of Amoora cucullata.
- To elucidate the chemical structure of the novel compound cucullamide.
- To identify known compounds co-isolated from the plant extract.
Main Methods:
- Extraction and isolation of compounds from Amoora cucullata leaves.
- Structure elucidation using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS) for molecular formula determination.
Main Results:
- Isolation and identification of a new putrescine bisamide derivative, cucullamide (1).
- Co-isolation of five known natural products: dasyclamide (2), ent-2beta-hydroxymanool (3), chrysin (4), apigenin (5), and kaempferol-3-O-beta-D-glucopyranoside (6).
- The structure of cucullamide was confirmed through comprehensive spectroscopic analyses.
Conclusions:
- Cucullamide is a novel natural product isolated from Amoora cucullata.
- The study expands the knowledge of the phytochemical profile of Amoora cucullata.
- The employed spectroscopic techniques were effective in elucidating the structure of the new compound.
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