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Updated: Jun 10, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Tissue microarrays from biopsy specimens.

Milton W Datta1, André A Kajdacsy-Balla

  • 1Hospital Pathology Associates and Department of Pathology, University of Minnesota, Minneapolis, MN, USA. Datta011@umn.edu

Methods in Molecular Biology (Clifton, N.J.)
|August 7, 2010
PubMed
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Tissue microarrays from needle core biopsies enable disease study with limited samples, offering insights into non-surgically treated tumors and revealing novel disease biomarkers.

Area of Science:

  • Oncology
  • Pathology
  • Biomarker Discovery

Background:

  • Limited tissue availability often hinders comprehensive disease analysis.
  • Nonsurgical treatment approaches for tumors necessitate alternative diagnostic and research methods.
  • Investigating biomarkers is crucial for understanding disease mechanisms and progression.

Purpose of the Study:

  • To explore the utility of tissue microarrays constructed from needle core biopsy specimens.
  • To demonstrate the value of these microarrays in studying diseases with scarce tissue.
  • To highlight their application in understanding tumors managed non-surgically.

Main Methods:

  • Construction of tissue microarrays using needle core biopsy samples.
  • Application of these microarrays in disease research.

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Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

  • Analysis of potential biomarkers within the constructed arrays.

    • Main Results:

    • Successful construction of tissue microarrays from limited biopsy samples.
    • Demonstrated feasibility of studying diseases with restricted tissue.
    • Provided insights into tumor characteristics relevant to nonsurgical treatments.
    • Identified potential new biomarkers for disease investigation.

    Conclusions:

    • Tissue microarrays from needle core biopsies are valuable for studying diseases with limited tissue.
    • These arrays offer critical insights into tumors treated with nonsurgical modalities.
    • The technique, though challenging, facilitates novel biomarker discovery in disease research.