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Updated: Jun 10, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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Copper-catalyzed Ficini [2 + 2] cycloaddition of ynamides

Hongyan Li1, Richard P Hsung, Kyle A DeKorver

  • 1Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.

Organic Letters
|August 10, 2010
PubMed
Summary

This study introduces the Ficini [2 + 2] cycloaddition reaction with N-sulfonyl-substituted ynamides. Copper(II) chloride and silver antimony hexafluoride catalyzed the first successful thermal cycloaddition of ynamides with enones.

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