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[Clinical studies and morphological response on ST-95 (fosfomycin)]
H Washida1, H Watanabe, Y Noguchi
1Department of Urology, Anjo Kosei Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|March 1, 1991
Summary
Fosfomycin (ST-95) effectively treated complex urinary tract infections in 81% of patients, including those with chronic catheterization. This antibiotic demonstrated significant bacterial reduction and induced morphological changes, suggesting it inhibits bacterial cell wall synthesis.
Area of Science:
- Microbiology
- Pharmacology
- Urology
Context:
- Complex urinary tract infections (UTIs) pose significant treatment challenges.
- Fosfomycin (ST-95) is an antibiotic investigated for its efficacy against UTIs.
- Bacterial morphology changes can indicate drug action mechanisms.
Purpose:
- To evaluate the clinical efficacy of ST-95 (fosfomycin) in patients with complex UTIs.
- To investigate the morphological alterations in urinary bacteria following ST-95 administration.
- To assess the safety and tolerability of ST-95 in this patient cohort.
Summary:
- ST-95 was administered intravenously to 22 inpatients with complex UTIs.
- Clinical effectiveness was observed in 81% of evaluable cases (13/16), with 75% effectiveness in patients with chronic catheterization.
- Microscopic examination revealed bacterial cell wall damage and a rapid reduction in viable bacterial counts, indicating ST-95's mechanism of action on cell wall synthesis.
Impact:
- ST-95 demonstrates satisfactory clinical outcomes for complex UTIs.
- The observed morphological changes provide insights into fosfomycin's antibacterial mechanism.
- This study supports fosfomycin as a viable treatment option for challenging urinary tract infections.