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08:59
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology
Thomas J Bandy1, Ashley Brewer, Jonathan R Burns
1University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, UK.
Chemical Society Reviews
|August 10, 2010
Summary
Oligonucleotides are emerging as versatile scaffolds for creating functional nanomaterials. This review highlights recent advances in covalently modifying DNA for diverse applications.
Area of Science:
- Biochemistry
- Nanotechnology
- Materials Science
Background:
- Oligonucleotides are increasingly utilized as scaffolds in supramolecular chemistry.
- Functional molecule design at the nanoscale is a rapidly advancing research area.
Purpose of the Study:
- To review recent progress in the covalent modification of DNA for nanomaterial design.
- To compare different attachment points for modifications on DNA strands.
Main Methods:
- Focus on covalent modifications of DNA, excluding non-covalent interactions.
- Analysis of both terminal and internal DNA modifications.
- Comparison of attachment sites: nucleobase, sugar moiety, and phosphodiester backbone.
Main Results:
- Demonstration of diverse functionalities incorporated into DNA strands via covalent modification.
- Examples highlight the versatility of modified oligonucleotides.
Conclusions:
- Covalent modification of oligonucleotides offers a powerful strategy for creating functional nanomaterials.
- The choice of attachment site influences the resulting molecular properties and applications.
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