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Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
[Pulmonary disease in polymyositis].
Direndra Hasmucrai1, Ana Cristina Mendes, Isabel Correia
1Serviço de Pneumologia I, Hospital de Santa Maria, CHLN, Lisboa, Portugal. diren2000@yahoo.com.br
Idiopathic inflammatory myopathies like polymyositis can manifest with rare interstitial lung disease. Chest X-rays are crucial for early detection, leading to timely diagnosis and treatment of polymyositis-associated organizing pneumonia.
Area of Science:
- Rheumatology
- Pulmonology
- Radiology
Background:
- Polymyositis and dermatomyositis are idiopathic inflammatory myopathies.
- Interstitial lung disease (ILD) is an uncommon complication, affecting approximately 10% of patients.
- Early identification of ILD is critical for managing these conditions.
Observation:
- A 75-year-old woman presented with constitutional symptoms including fever, weight loss, arthralgia, and myalgia.
- She exhibited symmetric proximal muscle weakness in both upper and lower limbs.
- Nonspecific interstitial changes were noted on her chest X-ray.
Findings:
- An exhaustive diagnostic workup led to the diagnosis of organizing pneumonia secondary to polymyositis.
- The patient's pulmonary involvement was identified despite the absence of respiratory symptoms.
- Treatment with glucocorticoids and mycophenolate resulted in positive clinical, analytical, and radiological outcomes.
Implications:
- This case highlights the significance of chest X-rays in screening for systemic diseases.
- Radiographic findings can prompt further investigation for polymyositis, even without overt respiratory complaints.
- Integrating imaging findings into the diagnostic pathway is essential for comprehensive patient care.
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