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Related Experiment Video

Updated: Jun 10, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Systemic lupus erythematosus (SLE): Trials and issues.

Ioana Moldovan¹, Ellen M Ginzler

¹Department of Rheumatology, Loma Linda University Medical Center, 11234 Anderson Avenue, Loma Linda, CA 11354, USA.

Discovery Medicine

|August 14, 2010

Summary

Systemic lupus erythematosus (SLE) clinical trials are complex due to varied symptoms. Recent studies focus on lupus nephritis, offering clearer treatment endpoints for this autoimmune disease.

Area of Science:

Immunology
Rheumatology
Clinical Trials

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by autoantibodies and fluctuating disease activity (flares and remissions).
Clinical trial design for SLE is challenging due to diverse manifestations and difficulties in measuring treatment response.
Evidence-based medicine, incorporating pathophysiology and epidemiology, is crucial for guiding SLE clinical trials and therapeutic decisions.

Purpose of the Study:

To provide an overview of recent clinical trials and case series in SLE published within the last two years.
To highlight significant developments in SLE research and clinical practice.
To reinforce key issues and challenges in conducting SLE clinical trials.

Main Methods:

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Last Updated: Jun 10, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Review of published clinical trials and case series in Systemic Lupus Erythematosus (SLE) from the past two years.

Focus on studies addressing lupus nephritis due to its more defined clinical endpoints.

Analysis of trial protocols and outcome measures relevant to SLE management.

Main Results:

Few large-scale prospective randomized studies have been published in SLE.
Most published studies focus on lupus nephritis, utilizing defined endpoints like serum creatinine, urine protein excretion, end-stage renal disease, and mortality.
Recent research is beginning to clarify effective therapeutic strategies and outcome measures for SLE.

Conclusions:

Clinical trials in SLE, particularly for lupus nephritis, are advancing with improved endpoint definitions.
Continued research and well-designed trials are essential for evidence-based management of SLE.
Addressing the complexity of SLE manifestations remains a key challenge in clinical research.