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Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients

Riccardo Lacchini1, Anna L B Jacob-Ferreira, Marcelo R Luizon

  • 1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 17, 2010
PubMed

Insights

Genetic variations in the matrix metalloproteinase-9 (MMP-9) gene are linked to hypertension and cardiac remodeling. Specific MMP-9 gene polymorphisms influence left ventricular remodeling in hypertensive individuals.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Hypertension Research

Background:

  • Matrix metalloproteinases (MMPs) play a role in cardiac remodeling.
  • Genetic polymorphisms in MMP genes can have functional consequences.
  • Investigating MMP-9 genetic variations in hypertension and left ventricular remodeling is crucial.

Purpose of the Study:

  • To determine the association between MMP-9 genetic polymorphisms and hypertension.
  • To assess the impact of MMP-9 genetic polymorphisms on left ventricular remodeling in hypertensive patients.

Main Methods:

  • Study included 173 hypertensive patients and 137 healthy controls.
  • Analyzed MMP-9 polymorphisms: C(-1562)T, -90 (CA)(14-24), and Q279R.
  • Used Haplo.stats and linear regression for association and effect analyses on LV remodeling parameters.

Main Results:

  • The MMP-9 -90 (CA)(14-24) "HH" genotype was associated with hypertension (P=0.0085).
  • One MMP-9 haplotype ("C, H, Q") showed a protective effect against left ventricular mass index (LVMI) and end-diastolic diameter increases (P=0.0490, P=0.0367).
  • Another MMP-9 haplotype ("T, H, Q") demonstrated detrimental effects on LVMI and end-diastolic diameter (P=0.0015, P=0.0057).

Conclusions:

  • MMP-9 gene polymorphisms may influence susceptibility to left ventricular remodeling in hypertensive patients.
  • Further research is needed to explore the clinical implications of these MMP-9 polymorphisms in hypertension.
Abstract

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