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Studies on the phenotype and karyotype of immortalized rabbit kidney epithelial cell lines
C MacDonald1, P Watts, B Stuart
1Department of Bioscience and Biotechnology, Todd Centre, Glasgow, Scotland.
Experimental Cell Research
|August 1, 1991
Abstract:
Differentiated mammalian cell lines can be isolated by immortalizing primary cells by transfection with DNA from plasmids containing sequences from SV40 early region. These cell lines show cytogenetic abnormalities but the degree of aneuploidy is considerably less than that observed in other established cell lines. No correlation was observed between the degree of differentiation of a clone and the extent of chromosomal damage.