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Updated: Jun 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Obesity predicts differential response to cancer prevention interventions among African Americans
Lucia A Leone1, Aimee S James, Marlyn Allicock
1Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA. lleone@email.unc.edu
Abstract:
Wellness for African Americans Through Churches was a randomized trial that tested the effectiveness of tailored print and video (TPV) and/or lay health advisors (LHA) at increasing recreational physical activity (RPA), fruit and vegetable (F&V) consumption, and colorectal cancer (CRC) screening in African American churches. Baseline data revealed lower screening and RPA rates among obese individuals but no weight-related differences in F&V consumption. This analysis examined if intervention effectiveness was also moderated by participant weight group. Regression analyses tested for interactions between intervention and weight group for screening and RPA. Weight group was found to be a moderator of intervention effectiveness (p = .02); normal and overweight individuals receiving the LHA intervention increased RPA more, whereas obese individuals responded better to TPV. For CRC screening, the interaction term was not significant; weight alone was related to screening at follow-up (p = .049), with obese individuals reporting less screening. These results suggest that weight tailoring may improve the effectiveness of behavior change interventions.
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