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Published on: March 11, 2014
Human papillomavirus in ameloblastoma
Maria Correnti1, Marcello Rossi, Maira Avila
1Instituto de Oncología y Hematología, MPPS, Instituto de Investigaciones Odontológicas, Universidad Central de Venezuela, Caracas, Venezuela. mcorrentip@yahoo.com
Summary
Human papillomavirus (HPV) DNA was detected in a third of intraosseous ameloblastomas, with HPV 6 being the most common genotype. Positivity was higher in unicystic ameloblastomas compared to solid types.
Area of Science:
- Oral pathology
- Oncology
- Virology
Background:
- Ameloblastomas are aggressive odontogenic tumors with high recurrence rates.
- Previous studies suggested Human Papillomavirus (HPV) presence in peripheral ameloblastomas.
- The role of HPV in intraosseous ameloblastomas remains largely unexplored.
Purpose of the Study:
- To investigate the presence and genotypes of HPV-DNA in intraosseous ameloblastomas.
- To correlate HPV detection with histological variants and clinical presentation.
Main Methods:
- Analysis of 18 intraosseous ameloblastoma cases using immunohistochemistry, CISH, nested-PCR, and HPV genotyping.
- Histological variants included solid multicystic, unicystic, plexiform, follicular, acanthomatous, and desmoplastic.
Main Results:
- HPV-DNA was detected in 33% of cases via nested-PCR; immunohistochemistry and CISH yielded negative results.
- HPV 6 was the most frequent genotype (66% of positive cases), with mixed genotypes also identified.
- HPV positivity was more prevalent in unicystic ameloblastomas (4/11) than solid types (2/7), often associated with koilocytic changes and dentigerous cysts.
Conclusions:
- HPV (both low and high risk) can be detected in intraosseous ameloblastomas.
- Unicystic ameloblastomas show a higher incidence of HPV positivity compared to solid ameloblastomas.
- The study did not find a correlation between HPV positivity and ameloblastoma recurrence rate.
