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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jun 10, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Detection of DNA mutations using a capacitive micro-membrane array.

Vasiliki Tsouti1, Christos Boutopoulos, Peristera Andreakou

  • 1Institute of Microelectronics NCSR Demokritos, Terma Patriarchou Grigoriou, Aghia Paraskevi, 15310 Athens, Greece. vasso@imel.demokritos.gr

Biosensors & Bioelectronics
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a novel DNA hybridization biosensor using ultrathin silicon membranes for capacitive readout. The sensor array detects DNA, even with single nucleotide mismatches, enabling sensitive genetic mutation analysis.

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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

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Related Experiment Videos

Last Updated: Jun 10, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • DNA hybridization is crucial for genetic analysis.
  • Existing biosensors face challenges in sensitivity and multiplexing.
  • Surface stress variations can indicate biological interactions.

Purpose of the Study:

  • To develop a novel biosensor for DNA hybridization detection.
  • To utilize ultrathin silicon membranes for enhanced sensitivity.
  • To create a multiplexed sensor array for simultaneous genetic analysis.

Main Methods:

  • Fabrication of a biosensor array with ultrathin silicon (Si) membranes.
  • Immobilization of probe DNA onto the membrane surface.
  • Capacitive readout to detect capacitance changes due to DNA hybridization-induced surface stress.
  • Testing with beta-thalassemia oligonucleotides for performance validation.

Main Results:

  • Demonstrated successful detection of DNA hybridization via capacitive readout.
  • Showcased the biosensor's ability to detect complementary DNA strands.
  • Confirmed the sensor's capability to discriminate single nucleotide mismatches.
  • Validated performance using beta-thalassemia oligonucleotide sequences.

Conclusions:

  • The developed biosensor array effectively detects DNA hybridization using ultrathin Si membranes.
  • The capacitive readout method provides a sensitive and reliable detection mechanism.
  • The sensor array's multiplexing capability supports concurrent detection of multiple DNA mutations.