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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Layers of the Epidermis01:21

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...

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Related Experiment Video

Updated: Jun 10, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Actinic keratoses: a comprehensive update.

Sherrif F Ibrahim1, Marc D Brown

  • 1University of Rochester School of Medicine and Dentistry, Department of Dermatology, Rochester, New York.

The Journal of Clinical and Aesthetic Dermatology
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

Actinic keratoses (AKs), linked to UV exposure, can progress to squamous cell carcinoma. Early treatment of these pre-cancerous skin lesions is crucial for preventing invasive disease.

More Related Videos

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Related Experiment Videos

Last Updated: Jun 10, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Actinic keratoses (AKs) are intra-epidermal neoplasms on a continuum with squamous cell carcinoma.
  • UV irradiation is a primary cause, leading to AKs in sun-exposed areas.
  • Early intervention can prevent progression to invasive squamous cell carcinoma.

Purpose of the Study:

  • To review established and emerging treatment modalities for actinic keratoses.
  • To focus on the efficacy and administration techniques of various therapies.
  • To discuss patient- and physician-associated variables influencing treatment choice.

Main Methods:

  • Review of current literature on actinic keratosis treatments.
  • Discussion of established therapeutic approaches.
  • Inclusion of recently adopted and experimental options.

Main Results:

  • Multiple effective treatment options exist for actinic keratoses.
  • Imiquimod and photodynamic therapy are now first-line treatments.
  • Combination therapy strategies are increasingly popular.

Conclusions:

  • Optimal treatment selection for AKs depends on individual patient and physician factors.
  • Various treatment modalities aim to limit the morbidity and mortality of squamous cell carcinoma.
  • Effective management of AKs is key to preventing invasive skin cancer.