Related Experiment Video
Updated: Jun 10, 2026

07:44
Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
Published on: April 28, 2016
Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis--a comparison
Tanja Deckert-Gaudig1, Volker Deckert
1Institute for Photonic Technology, Albert-Einstein. Str. 9, D-07745 Jena, Germany. tanja.deckert-gaudig@ipht-jena.de
Physical Chemistry Chemical Physics : PCCP
|August 24, 2010
Summary
Tip-enhanced Raman scattering (TERS) offers high-resolution chemical and topographic analysis. This perspective reviews TERS applications, especially in biology and medicine, highlighting its potential and future directions.
Area of Science:
- Spectroscopy and Microscopy
- Nanotechnology
- Chemical Analysis
Background:
- Tip-Enhanced Raman Scattering (TERS) emerged in 2000.
- TERS provides simultaneous chemical and topographic information.
- It achieves sub-100 nm resolution, enabling super-resolution structural analysis.
Purpose of the Study:
- To assess the development and capabilities of TERS.
- To focus on TERS applications in biology and medicine.
- To discuss the potential and challenges of TERS.
Main Methods:
- Review of TERS development and applications.
- Comparison with state-of-the-art imaging methods.
- Analysis of near-field spectroscopic and microscopic techniques.
Main Results:
- TERS is valuable for inorganic, organic, and biochemical specimens.
- The technique is crucial for super-resolution structural analysis.
- Significant progress has been made since TERS' discovery.
Conclusions:
- TERS holds great potential for biological and medical research.
- Addressing current challenges will expand TERS capabilities.
- Future projects aim to surpass existing limitations in nanoscale imaging.
Related Concept Videos
Raman Spectroscopy Instrumentation: Overview
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Raman Spectroscopy: Overview
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
