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Genetic variants in the C-reactive protein gene are associated with microangiopathic ischemic stroke

Gregor Kuhlenbaeumer1, Andreas Huge, Klaus Berger

  • 1Department of Neurology, Leibniz Institute for Atherosclerosis Research, University of Muenster, Muenster, Germany. g.kuhlenbaeumer@neurologie.uni-kiel.de

Cerebrovascular Diseases (Basel, Switzerland)
|August 25, 2010
PubMed

Insights

Genetic variations in the C-reactive protein (CRP) gene are linked to microangiopathic stroke, but not other types. This study analyzed CRP gene single-nucleotide polymorphisms (SNPs) in a large German population.

Area of Science:

  • Genetics
  • Cardiovascular Science
  • Neurology

Background:

  • C-reactive protein (CRP) is a known cardiovascular disease and ischemic stroke risk factor.
  • Genetic variations within the CRP gene influence CRP serum levels.
  • Previous studies on CRP gene polymorphisms and ischemic stroke have yielded inconsistent results.

Purpose of the Study:

  • To investigate the association between single-nucleotide polymorphisms (SNPs) in the CRP gene and ischemic stroke in a large German cohort.
  • To analyze specific CRP SNPs (rs3093075, rs1205, rs1130864, rs1800947) known to affect CRP serum concentrations.

Main Methods:

  • A case-control study involving 1,669 German patients with ischemic stroke.
  • Genotyping of 4 haplotype-tagging SNPs in the CRP gene.
  • Comparison with geographically matched controls from population-based studies.
  • Statistical analysis using SNP and haplotype approaches, with logistic regression for covariate adjustment.

Main Results:

  • All four analyzed CRP SNPs were in high linkage disequilibrium.
  • No significant association was found between CRP SNPs/haplotypes and ischemic stroke overall.
  • Three CRP SNPs (rs3093075, rs1130864, rs1800947) were significantly associated with microangiopathic stroke.
  • A common 4-SNP haplotype showed a protective effect, while two rarer haplotypes indicated susceptibility to microangiopathic stroke, even after adjustments and multiple testing correction.

Conclusions:

  • Genetic variations in the CRP gene are significantly associated with the risk of microangiopathic stroke.
  • No genetic association was observed for macroangiopathic or cardioembolic stroke subtypes.
  • These findings highlight the specific role of CRP gene polymorphisms in certain stroke etiologies.
Abstract

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