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Updated: Jun 9, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
[Changes and significance of T-lymphocytes subsets in severe hepatitis patients]
1National Hepatobiliary & Enteric Surgery Research Center, Sentral South University, Changsha 410001, China. xzbing@hotmail.com
Aim:
To study the changing of blood T-lymphocytes subsets in severe hepatitis patients and its effect.
Methods:
The T-lymphocytes subsets of 21 patients with severe hepatitis and 30 healthy volunteer were detected by flow cytometry. From the changes of T lymphocytes subsets we compared their related clinical prognosis of each case.
Results:
The average CD4(+) CD8(-), CD4(-) CD8(+) lymphocytes counts in severe hepatitis group were lower than the controls groups (P <0.05). And the the CD4(+)/CD8(+) ratios were higher than the control groups (P<0.05). The CD4(+) CD8(-), CD4(-) CD8(+) lymphocytes was lower than severe hepatitis dead group than the surviving group (P<0.05).
Conclusion:
The changes of T - lymphocytes subsets especially the elevation of counts CD4(+), CD8(+) lymphocytes may be one important marker to predict the clinical prognosis.
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