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Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications
P J Watts1, M C Davies, C D Melia
1Department of Pharmaceutical Sciences, University of Nottingham, U.K.
Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1990
Summary
This review details pharmaceutical microencapsulation via emulsification-solvent evaporation, offering guidelines for drug solubility and polymer selection. It explores microsphere characterization and potential clinical applications for advanced drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Microencapsulation is a key technology for controlled drug delivery.
- Emulsification-solvent evaporation is a widely used technique for creating microparticles.
Purpose of the Study:
- To review the emulsification-solvent evaporation technique for pharmaceutical microencapsulation.
- To provide guidelines for encapsulating drugs with varying aqueous solubilities.
- To discuss polymer properties and clinical potential of microencapsulated systems.
Main Methods:
- Detailed description of the emulsification-solvent evaporation process.
- Methods for microsphere characterization and performance assessment.
- Review of various encapsulating polymers and their properties.
Main Results:
- Guidelines for process development tailored to drug solubility (high or low).
- Comprehensive overview of microsphere characterization techniques.
- Examples of drug encapsulation using different polymers.
Conclusions:
- The emulsification-solvent evaporation method is versatile for pharmaceutical microencapsulation.
- Microsphere characterization is crucial for ensuring drug delivery performance.
- Microencapsulated systems hold significant promise for future clinical drug delivery.