[Activity of lysosomal hydrolases in various rabbit tissues in experimental atherosclerosis]

Activity of cathepsins D, B, C, H, L, acid lipase, acid cholesterol ester hydrolase, phospholipase A1, A2 and glucuronidase were studied in liver, small intestinal mucosa, intimal aortic cells, blood platelets and monocyte of rabbit after oral administration of cholesterol at daily dose of 300 mg/kg body weight within 100 days. Under this conditions distinct changes functional state of lysosomal systems were found in liver, monocyte and intima aortic cells. A possible mechanism of observed enzymological changes is discussed.