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Related Experiment Video

Updated: Jun 9, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Annular elastolytic giant cell granuloma].

F Djilali-Bouzina1, F Grange, S Krzisch

  • 1Service de dermatologie, hôpital Pasteur, Colmar cedex, France. jc.guillaume@wanadoo.fr

Annales De Dermatologie Et De Venereologie
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

Annular elastolytic giant cell granuloma (AEGCG) is a rare skin condition. Treatment with PUVA therapy and synthetic antimalarials led to a favorable outcome in a patient with AEGCG.

Related Experiment Videos

Last Updated: Jun 9, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Dermatology
  • Granulomatous Dermatoses

Background:

  • Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis.
  • Histologically characterized by multinucleated cells phagocytosing elastic fibers.

Observation:

  • A 67-year-old presented with pruritic annular lesions on the trunk and shoulders.
  • Lesions were histologically consistent with AEGCG.
  • Topical treatments and systemic corticosteroids were ineffective.

Findings:

  • PUVA therapy partially resolved trunk lesions but worsened lesions on the arms.
  • Synthetic antimalarial (hydroxychloroquine) treatment resulted in complete regression of all lesions.
  • This case highlights the efficacy of synthetic antimalarials in AEGCG.

Implications:

  • AEGCG is a rare condition with unknown etiology and empirical treatment.
  • Synthetic antimalarials offer a promising therapeutic option for AEGCG.
  • Further research into AEGCG treatment is warranted.