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Updated: Jun 9, 2026
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
[Diagnosis and surgical treatment of parathyroid carcinoma]
Jiarui Chen1, Jun Liu, Jiadong Wang
1Department of Otolaryngology Head and Neck Surgery, Renji Hospital of Shanghai Jiaotong University, China.
Objective:
To evaluate the diagnosis and surgical treatment of parathyroid carcinoma (PTC).
Method:
Clinical data of 4 PTC cases were analyzed retrospectively. Four patients all had palpable neck mass. Calcium level was (3.25 +/- 0.53) mmol/L, and PTH level was (1210.25 +/- 528.72) ng/L. Frozen section established diagnosis in only one case. Routine histopathology combined with immunohistochemistry established the diagnosis in 3 patients. Parathyroidectomy and ipsilateral subtotal thyroidectomy was performed in 3 patients; endoscopic parathyroidectomy was performed in one patient.
Result:
They were followed up for 8-60 months, Calcium level and PTH level were normal. No tumor recurrence and metastasis.
Conclusion:
The diagnosis of PTC is difficult before operation. Routine blood examinations: blood calcium, blood PTH; Imaging examinations: ultrasonography, CT are helpful to diagnosis. Frozen biopsy is not satisfactory. An initial en bloc resection of tumor and adjacent structures contributes most to the prognosis.
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