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Updated: Jun 9, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Antibodies in transplantation.
1Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA. plattjl@umich.edu
Discovery Medicine
|September 3, 2010
Summary
Antibodies against transplanted organs can indicate immune response and rejection. However, they can also protect grafts by blocking recognition and enhancing resistance, highlighting limitations in using antibodies as a sole immunity index.
Area of Science:
- Immunology
- Transplantation Biology
- Graft Rejection
Background:
- Antibodies against foreign antigens, particularly major histocompatibility antigens, are produced after transplantation.
- These antibodies are traditionally viewed as indicators of immunity and potential causes of graft injury and rejection.
Purpose of the Study:
- To review the limitations of using antibodies as a sole index of immune response in transplantation.
- To explore the dual role of antibodies in causing and preventing graft injury and rejection.
Main Methods:
- Literature review of studies on antibody-mediated rejection and enhancement.
- Analysis of mechanisms by which antibodies interact with grafts.
Main Results:
- Antibodies can be an incomplete index of immunity, sometimes failing to detect antibody-mediated rejection.
- Antibodies can paradoxically protect grafts through mechanisms like blocking immune recognition (enhancement), complement regulation, and inducing resistance to damage.
Conclusions:
- The role of antibodies in transplantation is complex, exhibiting both detrimental and protective effects.
- Relying solely on antibody detection as an index of immunity is insufficient due to their multifaceted functions in graft acceptance and rejection.
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