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Related Experiment Video

Updated: Jun 9, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Prostatic blue nevus.

Denisa Anderco¹, Elena Lazăr, Sorina Tăban

¹Department of Pathology, Emergency County Hospital, Timisoara, Romania. denisa_dobre@yahoo.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

|September 3, 2010

Summary

This summary is machine-generated.

A prostatic blue nevus, a rare melanin-containing lesion, was diagnosed in a 69-year-old patient. Histological and immunohistochemical analysis distinguished it from malignant melanoma, highlighting the importance of accurate classification.

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Area of Science:

Uropathology
Dermatopathology
Histology

Background:

Prostatic diseases often present with varied histological findings.
Melanin deposition in the prostate is uncommon, with potential for diagnostic confusion.
Distinguishing benign from malignant prostatic lesions is critical for patient management.

Observation:

A 69-year-old male presented with a large, homogenous prostate gland.
Prostatic chips obtained during transurethral resection exhibited unusual gray-brown-blackish coloration.
Initial appearance raised suspicion for malignant melanoma.

Findings:

Histological examination confirmed the presence of a prostatic blue nevus.
Histochemical (Fontana-Masson) and immunohistochemical (S100, HMB45) stains were crucial for diagnosis.
These stains differentiated the blue nevus from other melanin-containing prostatic lesions.

Implications:

Accurate diagnosis of prostatic blue nevus is essential to avoid misclassification as malignancy.
Understanding the spectrum of melanin-related prostatic lesions (blue nevus, melanosis, melanoma) is vital.
Correct identification impacts clinical decisions and patient prognosis.