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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Updated: Jan 10, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Recurrence Patterns in Breast Cancer: A Single-Center Retrospective Analysis.

Cristina Marinela Oprean1,2,3, Teodora Hoinoiu4,5,6, Larisa Maria Badau2,7

  • 1ANAPATMOL Research Center, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.

Journal of Clinical Medicine
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Recurrence of breast cancer is more common in advanced stages (II-III) and luminal B subtypes, particularly in postmenopausal women aged 51-70. Understanding these factors improves patient survival rates.

Keywords:
breast cancer recurrencebreast cancer treatmentmolecular subtypepostmenopausal statusretrospective analysissocioeconomic disparities

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Area of Science:

  • Oncology
  • Cancer Research
  • Epidemiology

Background:

  • Breast cancer recurrence poses significant challenges in diagnosis and treatment.
  • Risk of recurrence is elevated in advanced stages and within two years post-treatment.
  • Accurate staging and monitoring are vital for effective breast cancer management.

Purpose of the Study:

  • To identify key indicators of breast cancer recurrence.
  • To analyze recurrence patterns in relation to disease stage, molecular subtype, and patient demographics.
  • To improve disease-free and overall survival rates through better understanding of recurrence.

Main Methods:

  • Retrospective cohort study of 98 patients with invasive breast cancer recurrence (Stages I-III).
  • Data collected from 744 patients diagnosed and treated between 2007 and 2024.
  • Analysis included treatment history, disease stage, molecular subtype, tumor characteristics, and recurrence type.

Main Results:

  • Distant recurrence (71.4%) was more common than local recurrence (25.5%).
  • Stage II (40.8%) and Stage III (55.1%) breast cancer, and luminal B subtype (43.87%) were associated with higher recurrence risk.
  • Postmenopausal women aged 51-70, tumors 2-5 cm, and urban living environments showed increased recurrence rates.

Conclusions:

  • Advanced stage at diagnosis and luminal B subtype are key factors for local recurrence in postmenopausal women.
  • Patient age, primary tumor location, and prior aromatase inhibitor use may influence recurrence risk.
  • Further research on postmenopausal breast cancer recurrence is needed for precise disease understanding.