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Commissural transmission: maturational changes in humans
Science (New York, N.Y.)
|June 23, 1978
Summary
Latency differences in somatosensory evoked potentials reveal developmental trends linked to myelination and corpus callosum growth. Early ipsilateral activity suggests a posterior-parietal origin in the contralateral hemisphere.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Neurophysiology
Background:
- Somatosensory evoked potentials (SEPs) are crucial for assessing sensory pathway integrity.
- Understanding the maturation of the corpus callosum and myelination is key to interpreting neurological development.
- Ipsilateral and contralateral SEP pathways offer insights into interhemispheric and intrahemispheric processing.
Purpose of the Study:
- To investigate the maturational trends of latency differences in ipsilateral and contralateral somatosensory evoked potentials.
- To correlate these latency differences with the myelogenic timetable and corpus callosum development.
- To determine the origin of early ipsilateral SEP activity.
Main Methods:
- Analysis of latency differences between ipsilateral and contralateral SEPs.
- Correlation with established myelination timelines.
- Assessment of corpus callosum development.
- Examination of the distribution and projection patterns of early SEP activity.
Main Results:
- Significant maturational trends were observed in SEP latencies, aligning with myelination and corpus callosum development.
- Early ipsilateral SEP activity showed a distinct distribution pattern.
- Modality-specific projections of early ipsilateral activity were identified.
Conclusions:
- SEP latency differences provide a valuable marker for neurodevelopmental maturation.
- The findings suggest that early ipsilateral SEP activity originates from the contralateral posterior-parietal cortex.
- This study enhances our understanding of interhemispheric communication development.