[Delayed effect of 2-amino-4-acetylthiazolo[5, 4-b]indole hydrobromide on physical capability in mice]

The effect of 2-amino-4-acetylthiazolo[5, 4-b]indole hydrobromide (compound VM-605), a new antihypoxic drug and an analog of antihypoxant amtizole, on physical capability was studied in mice under swimming test conditions. The action of VM-605 depended both on the terms of testing upon administration of the drug and on the psychoemotional type of test animals. Maximum increase of the physical capacity in test mice was observed in delayed (up to 72 h) period after drug injection rather than in early (within 1-3 h) period. This increase was more typical of emotionally active and high-stress-resistant mice that were preliminarily selected in open field and forced swimming tests. It is suggested that delayed effects of VM-605 on physical capacity are related to the formation of active metabolites of the drug.